Withania somnifera, Dunal (Solanaceae) has long been used as a herb in Siddha and other indigenous medicine and has received intense attention in recent years for its analgesic, anti-inflammatory, and chemopreventive properties. The present study focuses on the effect of the fresh root of W. somnifera in the management of pain in degenerative disorders of lumbar region(lower back). A clinical trial was conducted with 20 samples and they were selected on the basis of inclusion and exclusion criteria. The fresh root of amukkura kizangu (Withania somnifera) is pulverized and gomiyam (Cow urine) is added to it. This medley is heated in woodfire and applied for 12 consecutive days in the region of pain. As amukkura possesses both anti-inflammatory and analgesic activity, application of herbal poultice on the painful area of the skin works by the mechanism of transdermal route of absorption. Pain was assessed before and after the study using back pain functional scale (BPFS). Significant changes in the score was observed which indicates a dramatic incline from a severity score of 20 – 30 to a better score of 35-50 out of total score 60. Thus amukkura kizangu pattru(poultice) was found to be more effective in management of pain in degenerative disorders(Arthritis) of lumbar region.