Neem (Azadirachta indica) is a medicinal plant also known as Margosa. It is a member of the Meliaceae family and it possess many benefits in curing skin ailments. It also has an antioxidant effect hence it enhances immunity and promotes health. It has been widely used in Unani practice. Neem is being used as a medicine all around the world especially in India in prevention and management of many diseases. It is considered as safe medicinal plant and exhibits very less adverse effects. It has wide variety of properties that can be used in treating many diseases. It possesses antibacterial and anti-inflammatory properties which help in soothing the skin. It contains nutrients like amino acids and polysaccharides. It is also known for its Daf-e- taffun, Daf-e-Ufoonat and Muhallil awram properties hence making it more beneficial to use in skin diseases.