Today stressful and busy life has indulged every individual in the problems related to physical and mental health, social isolation and financial crunch which leads to psychosomatic disturbances. The present study aims to evaluate the efficacy of Meditation in promoting mental health in the professional population. This was a prospective, randomized, case-control study on 55 subjects who were administered for a training module for 4 months. Individual measurements were carried out at the baseline and after 4 months of practice in almost similar conditions. Two standard psychological evaluation tools were used i.e. WHO Quality of Life. Following 4 months practice of PM, there was an improvement in all domains of WHOQOL ranging from 3 points to 5.7 that is physical health (42.1%) There was an improvement in depression in 7 of 12 subjects. Meditation is a cost-effective, non-invasive intervention with minimal risk of adverse effects and can be safely recommended for the promotion of mental health in Individuals.