Tuberculosis (TB) remains a major global health problem. It causes ill-health among millions of people each year and ranks as the second leading cause of death from an infectious disease worldwide after the human immunodeficiency virus Aims &Objective: To study the effects of tuberculosis sequelae on functional capacity in male patients compared with age-matched healthy individuals by using spirometry and six-minute walk test. Total 40 male tuberculosis sequelae patients who were referred to physiotherapy outpatient setup from chest medicine department were screened for the study. 30 tuberculosis patients who met the inclusion criteria and accepted to participate were included in the study. 8 tuberculosis sequelae patients who did not satisfy the inclusion criteria were excluded from the study. 5 patients were HIV positive, 1 patient had lower limb deformity, 2 patients had undergone recent cardiac surgery. 2 patients refused to participate in the study. 50 subjects diagnosed with osteoarthritis knee were included in the study. The data was collected by questionnaire form and was analyzed using SPSS 14.0 and graph pad 6.7 version. Correlation of was done using Pearson correlation coefficient. Result: The Mean difference of six-minute walk distance between Group A and Group B was 150.30. It was found to be statistically significant at P<0.0001(95% confidence interval) as measured by applying students unpaired t-test. From the present study, it is concluded that the result indicates that individuals with knee osteoarthritis report, episodes of knee instability during activities of daily living. Instability affects physical function which can be explained by contributions from other impairments such as knee pain, range of motion and quadriceps strength. There was a statistically significant increase in respiratory rate in both the groups with P< 0.0001for group A as measured by applying Wilcoxon matched-pairs signed-ranks test & P< 0.0001 for group B as measured by applying paired t-test. The mean change in respiratory rate was statistically significant between Group A & Group B with P< 0.0001 as measured by Mann-Whitney Test. The present study was attempted to analyses the effects of tuberculosis sequelae on functional capacity in male patients compared with age-matched healthy individuals by using spirometry and six-minute walk test. There was a significant difference in physical functional capacity between a group of normal middle-aged people and those with tuberculosis sequelae. In the TB sequelae group, there was a considerable impact of TB sequelae on cardio-respiratory endurance which affects the daily activities.