Mycobacterium Abscessus is a rapidly growing non-tuberculous mycobacterium known for its intrinsic resistance to numerous antibiotics, posing significant clinical challenges, especially for patients with cystic fibrosis and immunocompromised individuals. The advent of cryo-electron microscopy (Cryo-EM) has transformed structural biology by allowing near-atomic resolution visualization of macromolecular complexes, providing valuable insights into mechanisms of antibiotic resistance. This paper reviews the structural features of the M. Abscessus ribosome as elucidated by advanced Cryo-EM techniques, highlighting unique ribosomal RNA (rRNA) modifications and protein compositions that contribute to antibiotic resistance. By understanding these structural peculiarities, this research paves the way for developing novel therapeutic strategies targeting M. Abscessus.