For the frequent communication between the integrated circuits in an electronic system, which is designed to work in a group rather than a standalone unit, it becomes necessary to adapt serial communication, which is an effective and simple protocol, that provides efficient communication among these various components as compared to parallel communication in terms of the pin count and the ease of implementation. The two most widely accepted, tried and true serial global standards are Serial Peripheral Interface (SPI) and Inter-Integrated Circuit (I2C), which are used for inter-chip and intra-chip serial communication for low or medium bandwidth. The Paper’s focus is on the simulation of SPI and I2C protocols.