The world's two most powerful economies, China and the United States rely on the global digital domain for economic productivity, societal well-being, and national security. At the same time, governments and companies alike are becoming increasingly concerned about the security and reliability of their information systems, even as there remains significant ambiguity about the true nature of the threats and the most effective ways of addressing them. In recent years, the security of global information networks has been a contentious issue in US-China relations. Against this backdrop, this paper seeks to appraise and analyze the variations in strategies and methods used by the United States and China to pursue their military and economic interests in the cyber domain. This paper concludes by outlining the threat landscape that characterizes US-China relations in cyberspace, as well as maps the way forward for bridging gaps in trust and strengthening international cooperation frameworks.